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Application of Tetrode Technology for Analysis of Changes in Neural Excitability of Medial Vestibular Nucleus by Acute Arterial Hypotension
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Young Kim, Ho Koo, Byung Rim Park, Se Jin Moon, Seung-Bum Yang, Min Sun Kim
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Res Vestib Sci. 2018;17(4):142-151. Published online December 21, 2018
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DOI: https://doi.org/10.21790/rvs.2018.17.4.142
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 Abstract
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- Objectives
Excitability o medial vestibular nucleus (MVN) in the brainstem can be affected by changes in the arterial blood pressure. Several animal studies have demonstrated that acute hypotension results in the alteration of multiunit activities and expression of cFos protein in the MVN. In the field of extracellular electrophysiological recording, tetrode technology and spike sorting algorithms can easily identify single unit activity from multiunit activities in the brain. However, detailed properties of electrophysiological changes in single unit of the MVN during acute hypotension have been unknown.
Methods
Therefore, we applied tetrode techniques and electrophysiological characterization methods to know the effect of acute hypotension on single unit activities of the MVN of rats.
Results
Twoor3typesofunitcouldbeclassifiedaccordingtothemorphologyofspikes and firing properties of neurons. Acute hypotension elicited 4 types of changes in spontaneous firing of single unit in the MVN. Most of these neurons showed excitatory responses for about within 1 minute after the induction of acute hypotension and then returned to the baseline activity 10 minutes after the injection of sodium nitroprusside. There was also gradual increase in spontaneous firing in some units. In contrast small proportion of units showed rapid reduction of firing rate just after acute hypotension. Conclusions: Therefore, application of tetrode technology and spike sorting algorithms is another method for the monitoring of electrical activity of vestibular nuclear during acute hypotension.
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Anatomy and Physiology of the Autonomic Nervous System
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Byung Rim Park
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Res Vestib Sci. 2017;16(4):101-107. Published online December 15, 2017
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DOI: https://doi.org/10.21790/rvs.2017.16.4.101
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Crossref
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Abstract
PDF
- The autonomic nervous system (ANS) integrates the function of the internal organs for the homeostasis against various external environmental changes. The efferent components of the ANS are regulated by sensory signals arising from the viscera as well as non-visceral organs. The central neural networks that integrate these sensory signals and modify visceral motor output are complex, and synaptic reflexes formed in the brainstem and spinal cord integrate behavioral responses and visceral responses through the central neural networks. A detailed understanding of the neural network presented above may explain the role of the vestibular system on the homeostasis more extensively.
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Citations
Citations to this article as recorded by  - Sound stimulation using the individual's heart rate to improve the stability and homeostasis of the autonomic nervous system
Daechang Kim, Nahyeon Kim, Younju Lee, Sungmin Kim, Jiyean Kwon
Physiological Reports.2023;[Epub] CrossRef - A Study on Resonance Sound Stimulation Using an Individual's Heart Rate to Improve the Stability and Homeostasis of the Autonomic Nervous System
kim daechang, Seungbong Lee, Jaehoon Jeong, Sung Min Kim
SSRN Electronic Journal .2022;[Epub] CrossRef - Effect of Acupuncture at the Field of the Auricular Branch of the Vagus Nerve on Autonomic Nervous System Change
Sunjoo An, Dongho Keum
Journal of Korean Medicine Rehabilitation.2021; 31(2): 81. CrossRef - A Study on the Gamification of Television Broadcasting
Shin-kyu Kang
Korean Journal of Journalism & Communication Studi.2019; 63(3): 145. CrossRef - A Clinical Study on the Relationship between Pattern and Ryodoraku Test Identifications for Patients with Functional Dyspepsia
Whee-hyoung Ko, Na-yeon Ha, Seok-jae Ko, Jae-woo Park, Jin-sung Kim
The Journal of Internal Korean Medicine.2019; 40(3): 369. CrossRef
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Anatomy and physiology of the autonomic nervous system
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Byung Rim Park
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Received November 14, 2017 Accepted November 25, 2017 Published online November 25, 2017
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[Accepted]
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Abstract
- 자율신경계는 다양한 외적 환경의 변화에 대하여 내적 환경을 일정하게 유지하는 항상성을 위하여 내장기관의 기능을 통합 조절한다. 자율신경계 조절의 원심성분인 교감신경과 부교감신경은 내장기관뿐만 아니라 비내장기관으로부터 발생한 구심성 감각신호에 의하여 조절된다. 이러한 감각신호를 통합하고 내장운동 출력을 변화시키는 중추신경회로망은 복잡하며, 뇌간과 척수에서 형성된 시냅스반사는 중추뇌신경회로를 통하여 행동반응과 내장반응을 통합하여 조절한다. 이상에서 제시한 신경회로망을 상세하게 이해한다면 전정기관이 항상성에 미치는 역할을 보다 광범위하게 설명할 수 있을 것이다.
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