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Saccadic oscillations as a possible indicator of dizziness due to choline esterase inhibitors: an observational study with video-oculography
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Ileok Jung, Moon-Ho Park, Ji-Soo Kim
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Res Vestib Sci. 2024;23(3):101-105. Published online September 15, 2024
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DOI: https://doi.org/10.21790/rvs.2024.015
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 Abstract
 PDF Supplementary Material
- Introduction: Cholinesterase inhibitors (ChEIs) are widely used to treat mild to moderate Alzheimer disease and vascular dementia. Even though dizziness due to medication of ChEIs has been ascribed to adverse effects on the cardiovascular or central nervous system, the mechanisms remain unclear and objective indicators are not available.
Methods
We recorded the eye movements using video-oculography in three patients who developed dizziness and unsteadiness after initiation or increment of ChEI, donepezil (Aricept).
Results
The patients showed frequent saccadic oscillations that improved after discontinuation of ChEI.
Conclusions
Frequent saccadic oscillations may be an indicator of dizziness in patients taking ChEIs.
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Rotatory Vertebral Artery Syndrome in Foramen Magnum Stenosis
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Ileok Jung, Jin-Man Jung, Moon-Ho Park
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Received November 21, 2018 Accepted December 5, 2018 Published online December 5, 2018
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[Accepted]
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Abstract
- Reversible vertebral artery syndrome (RVAS) is characterized by recurrent attacks of vertigo, nystagmus, and syncope induced by compression of the vertebral artery during head rotation. A 60-year old man with atlas vertebrae fracture. presented recurrent attacks of positional vertigo. Left-beat, upbeat and count clock-wise torsional nystagmus occurred after lying down and bilateral head roll (HR) showing no latency or fatigue. MRI revealed foramen magnum stenosis (FMS) and dominancy of right vertebral artery (VA). The flow of the right VA on trans-cranial Doppler decreased significantly during left HR. The slower the velocity was, the more the nystagmus was aggravated. RVAS can be evoked by FMS causing compression of the VA. And the nystagmus might be aggravated according to the blood flow insufficiency.
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