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Research in Vestibular Science > Volume 11(4); 2012 > Article
Research in Vestibular Science 2012;11(4): 131-137.
급성 저혈압 후 내측 전정신경핵에서 대사성 글루탐산염 수용체 발현
, , , , , 최명애1, 김나리1, 박상언1, 박병건2, 김민선1, 박병림1
1원광대학교 의과대학 생리학교실 및 원광뇌과학연구소, 2광주여자대학교 식품영양학과
Expression of Metabotropic Glutamate Receptors in the Medial Vestibular Nucleus Following Acute Hypotension in Rats
Myoung Ae Choi, Nari Kim, Sang Eon Park, Byung Geon Park, Min Sun Kim, Byung Rim Park
1Department of Physiology, Wonkwang University School of Medicine, and Brain Science Institute at Wonkwang University, Iksan, Korea. byungp@wku.ac.kr
2Department of Food and Nutrition, Kwangju Women's University, Gwangju, Korea.
ABSTRACT
Background and Objectives:   Acute hypotension induces expression of c-Fos protein and phosphorylated extracellular signal-regulated kinase (pERK), and glutamate release in the vestibular nuclei. Expression of c-Fos protein and pERK is mediated by the excitatory neurotransmitter, glutamate. In this study, the signaling pathway of glutamate in the vestibular nuclei following acute hypotension was investigated.
Materials and Methods:  
Expression of metabotropic glutamate receptors (mGluRs) was measured by Western blotting in the medial vestibular nucleus following acute hypotension in rats.
Results:  
Expression of pGluR1 Ser831, a subtype of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, peaked at 30 minutes after acute hypotension insult, and expression of pNR2B, a subtype of N-methyl-D-aspartate (NMDA) receptors, peaked at 2 hours after acute hypotension insult. Acute hypotension induced expression of Homer1a and group I mGluR in the medial vestibular nucleus. Expression of mGluR1 and mGluR5 peaked at 6 hours following acute hypotension insults.
Conclusion:  
These results suggest that afferent signals from the peripheral vestibular receptors, resulting from acute hypotension insult, are transmitted through group I mGluRs as well as AMPA and NMDA receptors in the vestibular system.
Keywords: Metabotropic glutamate receptor; Ionotropic glutamate receptor; Homer1a; Medial vestibular nucleus; Acute hypotension
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