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Research in Vestibular Science 2012;11(2): 51-58.
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| 전하소뇌동맥 차단 후 내측 전정신경핵에서 c-Fos 단백발현에 대한 말초전정수용기의 역할 |
| , , , , , 김나리1, 이재희1, 최명애1, 박병건2, 김민선1, 박병림1 |
| 1원광대학교 의과대학 생리학교실 및 원광뇌과학연구소, 2광주여자대학교 식품영양학과 |
| Role of the Peripheral Vestibular End Organ in the Expression of c-Fos Protein in the Medial Vestibular Nucleus Following Occlusion of the Anterior Inferior Cerebellar Artery |
| Nari Kim, Jae Hee Lee, Myoung Ae Choi, Byung Geon Park, Min Sun Kim, Byung Rim Park |
1Department of Physiology, Wonkwang University School of Medicine, and Brain Research Institute at Wonkwang University, Iksan, Korea. byungp@wku.ac.kr
2Department of Food and Nutrition, Kwangju Women's University, Gwangju, Korea. |
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| ABSTRACT |
Background and Objectives: The present study investigated the role of the peripheral vestibular end organ in vestibular symptoms and temporal changes in expression of c-Fos protein in the vestibular nuclei following anterior inferior cerebellar artery (AICA) occlusion using rats with unilateral or bilateral labyrinthectomy.
Materials and Methods: Expression of c-Fos protein in the vestibular nuclei was measured 2, 12, 24, and 48 hours after AICA occlusion.
Results: Unilateral AICA occlusion significantly induced expression of c-Fos protein bilaterally in the medial, inferior, superior, and lateral vestibular nuclei. Following AICA occlusion, the medial vestibular nucleus (MVN) showed the highest expression of c-Fos protein among the 4 vestibular nuclei. The expression of c-Fos protein was asymmetric between the bilateral MVN, showing higher expression in the MVN contralateral to the side of AICA occlusion compared to the ipsilateral MVN. The degree of asymmetry in c-Fos protein expression between the bilateral MVN peaked 12 hours after AICA occlusion. The expression of c-Fos protein gradually decreased 24 hours after AICA occlusion and returned to control levels 48 hours after AICA occlusion. Unilateral labyrinthectomy significantly decreased expression of c-Fos protein in the MVN ipsilateral to the side of labyrinthectomy following AICA occlusion. Moreover, bilateral labyrinthectomy significantly decreased expression of c-Fos protein in the bilateral MVN flowing AICA occlusion.
Conclusion: These results suggest that afferent signals from the peripheral vestibular end organ are crucial to the expression of c-Fos protein in the MVN following AICA occlusion and that expression of c-Fos protein is sustained for 24 hours after AICA occlusion. |
| Keywords:
Vertebrobasilar insufficiency; Anterior inferior cerebellar artery occlusion; c-Fos protein; Vestibular system; Labyrinthectomy |
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