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Research in Vestibular Science > Volume 11(1); 2012 > Article
Research in Vestibular Science 2012;11(1): 8-13.
니트로글리세린을 이용한 양성 반복현훈과 전정 편두통의 감별: 예비연구
, , , , , 신종욱1, 정성해1, 오지은1, 이애영1, 김재문1, 김지수2
1충남대학교 의과대학 신경과학교실, 2서울대학교 의과대학 분당서울대병원 신경과학교실
Can Nitroglycerin Differentiate Benign Recurrent Vertigo From Vestibular Migraine? A Preliminary Study
Jong Wook Shin, Seong Hae Jeong, Ji Eun Oh, Ae Young Lee, Jae Moon Kim, Ji Soo Kim
1Department of Neurology, Chungnam National University Hospital, Chungnam National University College of Medicine, Daejeon, Korea. mseaj@hanmail.net
2Department of Neurology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea.
Background and Objectives:   Nitroglycerin (NTG), a donor of nitric oxide, is known to provoke migraine attacks in patients with migraine. However, this effect was not explored in patients with benign recurrent vertigo (BRV). To infer the mechanism of BRV, we evaluated provocative effects of NTG in patients with vestibular migraine (VM) and BRV compared with normal controls.
Materials and Methods:  
Thirteen patients with recurrent vertigo, 8 with VM and 5 with BRV, and 5 healthy controls received intravenous infusion of 0.5 μg/kg/min NTG over 20 minutes. Headache intensity (visual analog scale) and associated symptoms were recorded at baseline and every 10 minutes for an hour. And the subjects were also asked to complete a headache diary every hour for another 12 hours.
In contrast to normal controls (2/5, 40%, p=0.035) and the patients with BRV (1/5, 20%, p=0.007), all patients with VM (8/8, 100%) had migraine attacks after NTG injection. However, there was no difference in the proportion of the patients with migraine attacks after NTG injection between normal controls and the patients with BRV.
In contrast to the patients with VM, patients with BRV are not sensitive to nitric oxide. These results suggest that the pathophysiology of BRV may be different from that of VM.
Keywords: Benign recurrent vertigo; Vestibular migraine; Nitroglycerin
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