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Research in Vestibular Science > Volume 14(4); 2015 > Article
Research in Vestibular Science 2015;14(4): 101-109.
어지럼의 유전학적 접근
최재환
부산대학교 의학전문대학원 양산부산대학교병원 신경과
Genetic Approach of Dizziness
Jae Hwan Choi
Department of Neurology, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, Yangsan, Korea. rachelbolan@hanmail.net
ABSTRACT
Patients with recurrent vertigo/dizziness or unsteadiness are a heterogeneous group of complex disorders affecting the peripheral and central vestibular system. They represent a diagnostic challenge for the clinicians, and their genetic basis is largely not known. However, there are some cerebellar and vestibular disorders with a strong genetic background, such as episodic ataxia, spinocerebellar ataxia, vestibular migraine, Meniere’s disease, and autosomal dominant nonsyndromic deafness. Furthermore, recent advances in next generation sequencing technique are increasing the number of novel genes associated with cerebellar and vestibular disorders. In this article, we have summarized clinical and molecular genetics findings in neuro-otology.
Keywords: Genetic study; Dizziness; Cerebellar ataxia; Vestibulopathy
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