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Research in Vestibular Science > Volume 10(4); 2011 > Article
Research in Vestibular Science 2011;10(4): 115-120.
만성적 비특이적인 어지럼 환자에서 Prostaglandin I2의 경구 투약 효과
, , , , , 김지원1, 임현우1, 안윤숙1, 최승효2, 박홍주1, 정종우1
1울산대학교 의과대학 서울아산병원 이비인후과학교실, 2제주대학교 의과대학 제주대학병원 이비인후과학교실
Efficacy of Oral Prostaglandin I2 in Patients with Chronic Nonspecific Vertigo
Ji Won Kim, Hyun Woo Lim, Yun Suk An, Seung Hyo Choi, Hong Ju Park, Jong Woo Chung
1Department of Otolaryngology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. jwchung@amc.seoul.kr
2Department of Otolaryngology, School of Medicine, Jeju Hospital, Jeju National University, Jeju, Korea.
ABSTRACT
Background and Objectives:   The aim of this study is to evaluate the efficacy of prostaglandin I2 (PGI2) in the patients with chronic nonspecific vertigo using questionnaires of dizziness handicap inventory (DHI) and vertigo symptom scale (VSS).
Materials and Methods:  
Forty two patients with chronic nonspecific vertigo from May to December 2010 were enrolled in this study. We administered Berast (synthetic PGI2, beraprost sodium) 2 tablets (0.04 mg) twice a day to patients. Before and after 2, 4 weeks the end of administration patients underwent DHI and VSS for evaluation of state of the vertigo.
Results:  
Twenty four of 42 patients completed this clinical trial. Mean DHI scale score decreased significantly from 23.00 (±21.75) to 17.75 (±19.78) (p=0.004). All DHI subscales, physical, functional, and emotional factors, decreased after treatment of prostaglandin I2. VSS scale also showed significant decrease from 3.63 (±2.55) to 2.50 (±2.95) (p=0.044).
Conclusion:  
Prostaglandin I2 may be one of the treatments to improve symptoms in the patient s with chronic nonspecific vertigo.
Keywords: Prostaglandins; Vertigo; Drug therapy; Questionnaires
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