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J Korean Bal Soc > Volume 7(2); 2008 > Article
Journal of the Korean Balance Society 2008;7(2): 199-203.
Bickerstaff 뇌간뇌염과 유사한 증상을 보인 Methyl bromide 중독 2예
오선영, 서진영, 신병수, 서만욱, 김영현
전북대학교 의과대학 신경과학교실
Two Cases of Methyl Bromide Intoxication Mimicking Bickerstaff’s Brainstem Encephalitis
Jin Young Seo, Byoung Soo Shin, Man Wook Seo, Young Hyun Kim, Sun Young Oh
Department of Neurology, College of Medicine, Chonbuk National University, Jeonju, Korea. ohsun@chonbuk.ac.kr
ABSTRACT
Background: Methyl bromide is toxic to the central and peripheral nervous systems. Two patients with occupational exposure to this agent are described. Case: Two cases of previously healthy young men were involved. They had worked in a fumigating plant spraying fruits using methyl bromide for several months before admission. They showed general weakness, severe ataxia, bilateral dysmetria and bilateral lateral gaze limitation. And gaze-evoked nystagmus was observed in one of them. Brain MRI showed symmetrically increased signal intensity lesions including the brainstem, cerebellum and splenium of corpus callosum. After conservative treatment, they gradually improved over the next few weeks.
Conclusions:  
Symmetry and topography of our patients’ clinical and radiographic abnormalities support the proposal that methyl bromide exposure can produce symptoms similar to Bickerstaff’s brainstem encephalitis. Key words: Methyl bromide, Acute intoxication, Bickerstaff’s brainstem encephalitis
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