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J Korean Bal Soc > Volume 7(1); 2008 > Article
Journal of the Korean Balance Society 2008;7(1): 73-76.
항 GD1b IgG 항체와 연관된 천향성 체위성 안진 1예
, , , 정성해, 오건세, 신동익, 김지수
을지대학교 의과대학 신경과학교실, 대전을지대학병원 신경과1 충북대학교 의과대학 신경과학교실, 충북대학교병원 신경과2 서울대학교 의과대학 신경과학교실, 분당서울대학교병원 신경과3
A Case of Apogeotropic Positional Nystagmus Associated With Anti-GD1b IgG Antibody
Seong Hae Jeong, Gun Sei Oh, Dong Ick Shin, Ji Soo Kim
1Department of Neurology, Eulji University School of Medicine, Eulji University Hospital, Daejeon, Korea. mseaj@eulji.ac.kr
2Department of Neurology, Chungbuk National University, College of Medicine, Chungbuk National University Hospital, Korea.
3Department of Neurology, Seoul National University, College of Medicine, Seoul National University Bundang Hospital, Korea.
ABSTRACT
The binding of anti-GD1b IgG antibody to the cerebellar granular area or spinocerebellar Ia fibers in the peripheral nerves may cause the prominent cerebellar ataxia, mild quadriparesis and sensory dominant neuropathy. A 31-year woman presented with severe cerebellar ataxia and prominent apogeotropic positional nystagmus/vertigo. Increased anti-GD1b antibody IgG in her serum was noted. 18F-flurodeoxyglucose positron emission tomography (FDG-PET) showed decreased uptake in cerebellum. It is the first case of central positional nystagmus with anti-GD1b IgG antibody.
Keywords: Anti-GD1b IgG antibody; Apogeotropic nystagmus; Positron emission tomography
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