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J Korean Bal Soc > Volume 6(1); 2007 > Article
Journal of the Korean Balance Society 2007;6(1): 29-35.
급성 저혈압 유발 후 흰쥐의 내측 전정신경핵에서 Glutamate 수용체의 발현
, , , , , 이재희, 최명애, 최동옥, 김보경, 홍석민, 박병림
원광대학교 의과대학 생리학교실 및 원광대학교 전정와우기관연구센터1, 경희대학교 의과대학 이비인후과학교실2
Expression of Glutamate Receptors in the Medial Vestibular Nuclei following Acute Hypotension
Jae Hee Lee, Myoung Ae Choi, Dong Ok Choi, Bo Kyoung Kim, Seok Min Hong, Byung Rim Park
1Department of Physiology, Wonkwang University School of Medicine and Vestibulocochlear Research Center at Wonkwang University, Iksan, Korea. byungp@wku.ac.kr
2Department of Otorhinolaryngology and Head & Neck Surgery, College of Medicine, Kyunghee University, Seoul, Korea.
ABSTRACT
Acute hypotension induced excitation of electrical activities and expression of c-Fos protein and pERK in the vestibular nuclei. In this study, to investigate the excitatory signaling pathway in the vestibular nuclei following acute hypotension, expression of NR2A and NR2B subunits of glutamate NMDA receptor and GluR1 subunit of glutamate AMPA receptor was determined by RT-PCR and Western blotting in the medial vestibular nucleus 30 min after acute hypotension in rats. Acute hypotension increased expression of NR2A, NR2B, and pGluR1 in the medial vestibular nuclei. These results suggest that both of NMDA and AMPA glutamate receptors take part in transmission of excitatory afferent signals following acute hypotension.
Keywords: Vestibular nuclei; Acute hypotension; Glutamate receptor
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