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J Korean Bal Soc > Volume 5(1); 2006 > Article
Journal of the Korean Balance Society 2006;5(1): 9-14.
메니에르병의 병인으로서 ENaC Channelopathy의 가능성
박시내, 이병훈, 박경호, 홍명화, 이흥엽, 장기홍, 여상원
가톨릭대학교 의과대학 이비인후과학교실
Possibility of Epithelial Sodium Channelopathy as a Pathogenesis of Meniere's Disease
Shi Nae Park, Byung Hoon Lee, Kyung Ho Park, Myoung Hwa Hong, Heung Youp Lee, Ki Hong Chang, Sang Won Yeo
Department of Otolaryngology-HNS, The Catholic University of Korea College of Medicine, Seoul, Korea. swyeo@catholic.ac.kr
ABSTRACT
Background and Objectives:   Meniere's disease is a paroxysmal disorder with vertigo and hearing loss. Its episodic nature of vertigo attacks and responsiveness to diuretics is similar to several neurologic disorders with channelopathy. We performed this study to identify the possibility sodium channelopathy in the patients with Meniere's disease.
Materials and Method:   Thirty patients with definite Meniere's disease and 25 normal controls were included in this study. Clinical features of the patients with Meniere's disease were collected using dizziness chart. Whole blood was taken from all the patients with Meniere's disease and normal controls and used for DNA testing. α-ENaC gene was screened for mutations using direct DNA sequencing.
Results:   Patients with Meniere's disease in this study showed the various clinical features of onset age, number of attacks and hearing levels. Many of them showed the caloric response reduction and abnormal electrocochleogram. Genetic analysis did not identify any mutations or differences in α-ENaC gene in normal controls and the patients with Meniere's disease.
Conclusion:   Na channelopathy due to α-ENaC gene mutation might not be a pathogenesis of Meniere's disease. Further studies with other subunits of ENaC and other ion channel genes are needed to explore the possibility of channelopathy as a pathogenesis of Meniere's disease. Key Words : Meniere's disease, Channelopathy.
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