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Research in Vestibular Science > Accepted Articles
A case of postprandial dizziness/syncope relieved by alfa-glucosidase inhibitor
Hakyeu An1, Seong-Hae Jeong1, Hyun Jin Kim2, Eun Hee Sohn1, Ae Young Lee1, Jae Moon Kim1
1Department of Neurology, Chungnam National University Hospital, Daejeon, Korea, Daejeon, Korea
2Division of Endocrinology and Metabolism, Department of Internal Medicine, Chungnam National University School of Medicine, Daejeon, Korea., Daejeon, Korea
Correspondence  Seong-Hae Jeong ,Tel: 042-280-8057, Fax: 042-252-8654, Email: mseaj@hanmail.net
Received: February 15, 2018;  Accepted: March 7, 2018.  Published online: March 7, 2018.
A 74 year-old man presented with positional vertigo and prandial dizziness and syncope. He had experienced episodes of frequent dizziness and loss of consciousness for several months. He underwent total gastrectomy with esophagojejunostomy and brown anastomosis 30 year ago. Thirteen years ago, subtotal colectomy with ileo-descending colostomy was done due to colon cancer. And he also had mitral valve replacement and maze operation due to severe mitral valve stenosis and atrial fibrillation. After cardiac operation, he has sudden dizziness with diaphoresis and chalky face usually occurs especially within 30 minutes from the onset of eating. Sometimes this event was followed by several seconds of loss of consciousness, which caused recurrent events of falling. Neurological examination showed positional nystagmus compatible with benign paroxysmal positional vertigo arising from posterior semicircular canal of the right ear. The positional vertigo disappeared immediately after canalith repositioning maneuver. We tried to check vital signs and serum level of glucose during eating. Hyperglycemia (range: 210-466) was noted during eating, which is accompanied by her postprandial and prandial hypotension, up to 60/40 mmHg. The patient was prescribed 100 mg of the alfa-glucosidase, acarbose to be taken half an hour before each meal. Eventually, the treatment with acarbose controlled the prandial dizziness and hypotension associated with hyperglycemia followed by hypotension. Our patient suggests the acarbose could prevent postprandial dizziness and hypotension.
Keywords: prandial; dizziness; syncope; hypotension; alfa-glucosidase inhibitor
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Related article
Postprandial Dizziness/Syncope Relieved by Alfa-Glucosidase Inhibitor: A Case Report  2018 June;17(2)
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