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Research in Vestibular Science > Accepted Articles
원활추종운동 이득감소로 근피로도를 확인한 중증근무력증 2예
Ju-Hee Chae1, Hyun-June Shin1, Byoung-Soo Shin1, Man-Wook Seo1, Sun-Young Oh1
1Department of Neurology, Chonbuk National University Medical School and Hospital, Jeonju, Korea
2Biomedical Research Institute, Chonbuk National University Hospital, Jeonju, Korea
Correspondence  Sun-Young Oh ,Tel: 063-250-1590, Fax: 063-251-9363, Email: ohsun@jbnu.ac.kr
Received: April 9, 2019;  Accepted: June 3, 2019.  Published online: June 3, 2019.
ABSTRACT
Myasthenia Gravis (MG) is an autoimmune disease caused by autoantibodies to the acetylcholine receptors of the neuromuscular junction characterized by weakness and abnormal fatigability of the muscles. Therefore, the diagnosis of MG depends on the recognition of this distinctive pattern of fatigable weakness. Previous studies presented the diagnostic efficacy of saccadic eye movements in patients with ocular MG. We here in report two patients of ocular MG showing the fatigue effects during repetitive sustained smooth pursuit, and the effects of the administration of edrophonium on myasthenic smooth pursuit. Changes in smooth pursuits reflecting peripheral and secondary central mechanisms were demonstrated.
Keywords: Myasthenia Gravis; Video-oculography; Smooth pursuit; Fatigibility
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