Whole Cell Recording of the Vestibulocerebellum

Research in Vestibular Science > Volume 11(0); 2012 > Article

Research in Vestibular Science 2012;11(0): 60-66.

소뇌 퍼킨지 세포의 소엽 특이적 세포막 흥분성

김창희1, 김용규2

건국대학교 의과대학 이비인후과학교실1, 서울대학교 의과대학 생리학교실2

Whole Cell Recording of the Vestibulocerebellum

Chang-Hee Kim, MD1, Yong Gyu Kim, MSc2

1Department of Otorhinolaryngology-Head and Neck Surgery, Kunkuk University School of Medicine; and 2Department of Physiology, Seoul National University College of Medicine, Seoul, Korea

ABSTRACT

In the cerebellar vermis, each lobule receives different sensory information. Lobules III-V which are known as spinocerebellum receive major afferent input through ventral spinocerebellar tract, and lobule X which is known as vestibulocerebellum has extensive primary and secondary vestibular afferent. We hypothesized that Purkinje cells in different lobules may have different input-output functions with distinct membrane properties to encode different kinds of sensory modality. This study showed that intrinsic membrane properties vary widely between Purkinje cells in lobule III-V and X. Purkinje cells in lobule X exhibited more diverse firing patterns, and had wide dynamic range in their input-output curve not saturating their firing rates as readily as lobule III-V neurons. These findings are the first report, as far as we know, about the inter-lobular difference of intrinsic properties of Purkinje cells from the systematic comparison.