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Research in Vestibular Science > Volume 10(1); 2011 > Article
Research in Vestibular Science 2011;10(1): 12-18.
적외선과 웹캠을 이용한 일측 미로절제를 시행한 마우스의 원형 자유공간에서의 행동 지표 계측
김미주, 황현중, 정승원, 한규철
가천의과학대학교 의학전문대학원 길병원 이비인후과학교실
Measuring the Behavioral Parameters of Mouse Following Unilateral Labyrinthectomy in Round Free Field Using an Infrared Lamp and a Simple Webcam Camera
Mi Joo Kim, Hyun Jung Hwang, Seung Won Chung, Gyu Cheol Han
Department of Otorhinolaryngology-Head and Neck Surgery, Gachon University of Medicine and Science, Graduate School of Medicine, Incheon, Korea. hangckr@gmail.com
ABSTRACT
Background and Objectives:   In this research, movements of mouse after labyrinthectomy were analyzed to determine the degree of vestibular dysfunction and compensation.
Materials and Methods:  
By using an infrared lamp, mouse movements were recorded for 100 seconds in a dark room. The experimental area was manufactured as a circular space with a diameter of 60 cm. The movements of five mice labyrinthectomized on right side were observed and recorded at 3 hours, 9 hours and 120 hours after the operation, and also the ten mice of control group.
Results:  
The differences between the total moving distances and the rotating angle from the origin that set the center of round field between groups were analyzed with pictures of 1 frame per second. It is concluded that all 4 groups show significant differences between its mean rotation angle and total moving distances statistically. At 9 hours after right labyrinthectomy, mice tended to turn clockwise; but at 120 hours, there was no significant difference between clockwise and counter-clockwise rotation.
Conclusion:  
Measuring the movement of mouse in round free field can be the proper method to determine the degree of vestibular dysfunction and vestibular compensation. This test was time-saving and cost-effective method.
Keywords: Mouse; Vestibular function; Behavior test; Labyrinthectomy
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