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Original Article
- Intravenous Zoledronic Acid in Elderly Patients with Benign Paroxysmal Positional Vertigo and Osteoporosis
- Dong Won Kwack, Hyemi Lee, Dong Wook Kim
- Res Vestib Sci. 2020;19(3):95-98. Published online September 15, 2020
- DOI: https://doi.org/10.21790/rvs.2020.19.3.95
- 5,762 View
- 79 Download
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Abstract
PDF - Objectives
Benign paroxysmal positional vertigo (BPPV), a common cause of vertigo in the elderly, shares common pathogenic mechanisms with osteoporosis. We investigated the efficacy and safety of intravenous zoledronic acid in elderly patients with BPPV and osteoporosis.
Methods
We performed a 3-year observational study with elderly patients who were diagnosed with BPPV and osteoporosis. The recurrence of BPPV and changes in bone mineral densitometry (BMD) scores were evaluated one year after the administration of intravenous zoledronic acid.
Results
We enrolled 101 elderly patients with BPPV and 54 of them (53.5%) met the diagnostic criteria for osteoporosis. Intravenous zoledronic acid was administered in 51 patients. The recurrence of BPPV was observed in only two of 49 patients (4.1%) at 1 year’s follow-up. The mean lowest T-score of BMD improved from –3.23±0.51 to –3.05±0.58 (p=0.001).
Conclusions
Our study showed that the treatment of osteoporosis can be considered to prevent the recurrence of BPPV in the elderly. Further placebo-controlled studies are needed to estimate accurately the efficacy of zoledronic acid in the prevention of recurrence of BPPV in the elderly.
Review
- Medications as Risk Factor for Falls
- Ye Won Lee, Sung Il Nam
- Res Vestib Sci. 2016;15(4):101-106. Published online December 12, 2016
- DOI: https://doi.org/10.21790/rvs.2016.15.4.101
- 10,029 View
- 1,576 Download
- 3 Crossref
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Abstract
PDF
- Falls are the most common cause of accidents among the older population, leading to both fatal and non-fatal injuries. Falls is a syndrome resulting from the cumulative effect of various extrinsic and intrinsic factors. It is considered to be a multifactorial disorder. Medication use is considered a risk factor for falls. We reviewed medications associated with falls in older individuals. In geriatrics populations, polypharmacy is associated with falls. Medical doctors should be aware of the possibility that starting a new medication, such as antihypertensive agents, benzodiazepine, antidepressants, opioid agents and antihistamines, may act as a trigger for the onset of a fall.
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Citations
Citations to this article as recorded by
- A model for predicting fall experience in the elderly population over 65 years old: Decision tree analysis
Myeunghee Han
Journal of Korean Gerontological Nursing.2022; 24(4): 366. CrossRef - Medications and Falls Experiences among Older People
Jiyoon Han, Eunok Park
Journal of Korean Gerontological Nursing.2021; 23(4): 373. CrossRef - Triggers and Outcomes of Falls in Hematology Patients: Analysis of Electronic Health Records
Min Kyung Jung, Sun-Mi Lee
Journal of Korean Academy of Fundamentals of Nursi.2019; 26(1): 1. CrossRef
- A model for predicting fall experience in the elderly population over 65 years old: Decision tree analysis
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