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J Korean Bal Soc > Volume 4(2); 2005 > Article
Journal of the Korean Balance Society 2005;4(2): 225-229.
Gentamicin으로 손상된 기니픽의 전정기관에 저출력 레이저 조사가 미치는 영향
, , , 이정구1,<, 김명찬1, 임은석1, 김영생1
단국대학교 의과대학 이비인후-두경부외과학교실1, 의학 레이저 연구센터2
Effect of Low Power Laser Irradiation on Gentamicin-Damaged Vestibular System in Guinea Pigs
Chung Ku Rhee, Myoung Chan Kim, Eun Seok Lim, Young Saeng Kim
1Department of Otolaryngology-Head and Neck Surgery, College of Medicine, Dankook University, Cheonan, Korea. rheeck@dku.edu
2Medical Laser Research Center, College of Medicine, Dankook University, Cheonan, Korea.
ABSTRACT
Background and Objectives:  The purpose of this study was to investigate the characteristics of gentamicin-induced vestibulotoxicity of otolith organs and preventive effect of low power laser to vestibulotoxicity by assessing the result of earth vertical and the off vertical axis rotation tests.
Materials and Method:   Twenty guinea pigs were grouped into two groups, laser and no laser group. Vestibulotoxicity was induced by intratympanic injection of gentamicin. Prevention of the vestibulotoxicity was studied by irradiation of low power laser. Off vertical axis rotation tilted 30 degree relative to the earth vertical axis was applied to evaluate the otolithic function.
Results:   Gentamicin induced vestibulotoxicity was confirmed by gain decreasing in slow harmonic acceleration test and modulation decreasing in the off vertical axis rotation test. Prevention effect of low power laser to gentamicin induced vestibulotoxicity was confirmed by modulation maintaining in the off vertical axis rotation test and gain maintaining in the earth vertical axis rotation.
Keywords: Low level laser; Vestibular system; Gentamicin; Ototoxicity; Rotation test
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