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Journal of the Korean Balance Society 2003;2(2): 170-174.
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| Immunohistochemical Identification of Phosphorylated Extracellular Signal-Regulated Kinase1/2 in Rat Vestibular Nuclei by Unilateral Labyrinthectomy |
| 최명애, 최동옥, 김광영, 이문영, 박병림, 김민선 |
| 원광대학교 의과대학 생리학교실 |
| Immunohistochemical Identification of Phosphorylated Extracellular Signal-Regulated Kinase1/2 in Rat Vestibular Nuclei by Unilateral Labyrinthectomy |
| Myoung Ae Choi, Dong Ok Choi, Kwang Yong Kim, Moon Young Lee, Byung Rim Park, Min Sun Kim |
| Department of Physiology, Wonkwang University School of Medicine and Vestibulocochlear Research Center at Wonkwang University Iksan 570-749, South Korea. mskim@wonkwang.ac.kr |
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| ABSTRACT |
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This study evaluated the expression of phosphorylated signal-regulated kinase1/2 (pERK1/2), which is one of the main factors regulating transcription of the cfos oncogene in neurons, in the vestibular nuclei of Sprague-Dawley rats following unilateral labyrinthectomy (UL). Surgical UL was performed to eliminate afferent signals from the peripheral vestibular receptors in the inner ear, under a surgical microscope, 2 hours after anesthesia. Significant numbers of pERK1/2 immunoreactive neurons were seen in the superior, medial, and inferior vestibular nuclei. There were more pERK1/2 immunoreactive cells in the vestibular nuclei contralateral than in the vestibular nuclei ipsilateral to the injured labyrinth, which resulted in significant asymmetric expression of pERK1/2 immunoreactive cells. Subsequently, the pERK1/2 immunoreactivity decreased rapidly, disappearing 90 min after labyrinthectomy. No pERK1/2 labeling was seen in the lateral vestibular nucleus. These results suggest that intracellular signal pathways for the activation of extracellular signal-regulated kinase in the vestibular nuclei are involved in lesion-neural plasticity in the vestibular system. |
| Keywords:
Labyrinthectomy; pERK1/2; Vestibular Nucleus; Vestibular compensation |
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